Three-dimensional linear modeling of tongue: articulatory data and models

Volume images of tongue were acquired by MRI from one subject uttering a corpus representative of French allophone articulations. Supplementary images of hard palate, jaw, and hyoid bone were acquired by CT. The three-dimensional tongue surface outline was represented, for each of the 46 articulations of the corpus, by a mesh obtained by fitting a generic mesh to the set of tongue contours traced from the MR images. Jaw and hyoid bone positions were also determined. The set of the 3D coordinates of all vertices of the tongue mesh constituted the variables on which linear component analysis was applied. Six linearly independent components were found to explain 87 % of the variance of the tongue data. The associated parameters that control the linear articulator tongue model are related to jaw and hyoid positions, and to the actions of tongue muscles such as the genioglossus, the hyoglossus or the styloglossus. In addition, it was shown that the full 3D tongue surface is predictable from its 2D midsagittal contour with a mere 13.6 % increase in the overall full 3D reconstruction RMS error, which confirms quantitatively previous results. Finally, the tongue volume was found to depart by at most ±5% from its mean over the corpus, which supports the hypothesis of tongue tissue incompressibility for speech

Measuring a Light Neutralino Mass at the ILC: Testing the MSSM Neutralino Cold Dark Matter Model

The LEP experiments give a lower bound on the neutralino mass of about 46 GeV which, however, relies on a supersymmetric grand unification relation. Dropping this assumption, the experimental lower bound on the neutralino mass vanishes completely. Recent analyses suggest, however, that in the minimal supersymmetric standard model (MSSM), a light neutralino dark matter candidate has a lower bound on its mass of about 7 GeV. In light of this, we investigate the mass sensitivity at the ILC for very light neutralinos. We study slepton pair production, followed by the decay of the sleptons to a lepton and the lightest neutralino. We find that the mass measurement accuracy for a few-GeV neutralino is around 2 GeV, or even less if the relevant slepton is sufficiently light. We thus conclude that the ILC can help verify or falsify the MSSM neutralino cold dark matter model even for very light neutralinos.Comment: 7 pages, 1 figure; references adde

Posttransplant lymphoproliferative disorders in neuronal xenotransplanted macaques

Posttransplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of lymphoid proliferations that occur in the setting of depressed T-cell function due to immunosuppressive therapy used following solid organ transplantation, hematopoietic stem cell transplantation, and also xenotransplantation. In the present study, 28 immunosuppressed parkinsonian Macaca fascicularis were intracerebrally injected with wild-type or CTLA4-Ig transgenic porcine xenografts to identify a suitable strategy to enable long-term cell survival, maturation, and differentiation. Nine of 28 (32%) immunosuppressed primates developed masses compatible with PTLD, located mainly in the gastrointestinal tract and/or nasal cavity. The masses were classified as monomorphic PTLD according to the World Health Organization classification. Immunohistochemistry and polymerase chain reaction (PCR) analyses revealed that the PTLDs were associated with macaca lymphocryptovirus as confirmed by double-labeling immunohistochemistry for CD20 and Epstein-Barr nuclear antigen 2 (EBNA-2), where the viral protein was located within the CD20+ neoplastic B cells. In sera from 3 distinct phases of the experimental life of the primates, testing by quantitative PCR revealed a progression of the viral load that paralleled the PTLD progression and no evidence of zoonotic transmission of porcine lymphotropic herpesvirus through xenoneuronal grafts. These data suggest that monitoring the variation of macaca lymphocryptovirus DNA in primates could be used as a possible early diagnostic tool for PTLD progression, allowing preemptive treatment such as immunosuppression therapy reduction

Use of dual carbon–chlorine isotope analysis to assess the degradation pathways of 1,1,1-trichloroethane in groundwater

Compound-specific isotope analysis (CSIA) is a powerful tool to track contaminant fate in groundwater. However, the application of CSIA to chlorinated ethanes has received little attention so far. These compounds are toxic and prevalent groundwater contaminants of environmental concern. The high susceptibility of chlorinated ethanes like 1,1,1-trichloroethane (1,1,1-TCA) to be transformed via different competing pathways (biotic and abiotic) complicates the assessment of their fate in the subsurface. In this study, the use of a dual C-Cl isotope approach to identify the active degradation pathways of 1,1,1- TCA is evaluated for the first time in an aerobic aquifer impacted by 1,1,1-TCA and trichloroethylene (TCE) with concentrations of up to 20 mg/L and 3.4 mg/L, respectively. The reaction-specific dual carbon-chlorine (C-Cl) isotope trends determined in a recent laboratory study illustrated the potential of a dual isotope approach to identify contaminant degradation pathways of 1,1,1-TCA. Compared to the dual isotope slopes (Δδ13C/Δδ37CI) previously determined in the laboratory for dehydrohalogenation/hydrolysis (DH/HY, 0.33 ± 0.04) and oxidation by persulfate (∞), the slope determined from field samples (0.6 ± 0.2, r2 = 0.75) is closer to the one observed for DH/HY, pointing to DH/HY as the predominant degradation pathway of 1,1,1-TCA in the aquifer. The observed deviation could be explained by a minor contribution of additional degradation processes. This result, along with the little degradation of TCE determined from isotope measurements, confirmed that 1,1,1-TCA is the main source of the 1,1-dichlorethylene (1,1-DCE) detected in the aquifer with concentrations of up to 10 mg/L. This study demonstrates that a dual C-Cl isotope approach can strongly improve the qualitative and quantitative assessment of 1,1,1-TCA degradation processes in the field

BWO based imaging for control of MWCNTs polymer composites homogeneity

Terahertz imaging system based on backward wave oscillator for the defectoscopy of composites in the industry is presented. At a frequency of 874 GHz images of multiwall carbon nanotube agglomerates in a composite are obtained. The possibility of detecting inhomogeneities using level filtering is shown

A real-time articulatory visual feedback approach with target presentation for second language pronunciation learning

International audienceArticulatory information can support learning or remediating pronunciation of a second language (L2). This paper describes an electromagnetic articulometer-based visual-feedback approach using an articulatory target presented in real-time to facilitate L2 pronunciation learning. This approach trains learners to adjust articulatory positions to match targets for a L2 vowel estimated from productions of vowels that overlap in both L1 and L2. Training of Japanese learners for the American English vowel /ae/ that included visual training improved its pronunciation regardless of whether audio training was also included. Articulatory visual feedback is shown to be an effective method for facilitating L2 pronunciation learning

How to Stop the Bleed: First Care Provider model for developing public trauma response beyond basic hemorrhage control

INTRODUCTION: Since 2013, the First Care Provider (FCP) model has successfully educated the non-medical population on how to recognize life-threatening injuries and perform interventions recommended by the Committee for Tactical Emergency Casualty Care (C-TECC) and the Hartford Consensus in the disaster setting. Recent programs, such as the federal Stop The Bleed campaign, have placed the emphasis of public training on hemorrhage control. However, recent attacks demonstrate that access to wounded, recognition of injury, and rapid evacuation are equally as important as hemorrhage control in minimizing mortality. To date, no training programs have produced a validated study with regard to training a community population in these necessary principles of disaster response. METHODS: In our study, we created a reproducible community training model for implementation into prehospital systems. Two matched demographic groups were chosen and divided into trained and untrained groups. The trained group was taught the FCP curriculum, which the Department of Homeland Security recognizes as a Stop the Bleed program, while the untrained group received no instruction. Both groups then participated in a simulated mass casualty event, which required evaluation of multiple victims with varying degree of injury, particularly a patient with an arterial bleed and a patient with an airway obstruction. RESULTS: The objective measures in comparing the two groups were the time elapse until their first action was taken (T1A) and time to their solution of the simulation (TtS). We compared their times using one-sided t-test to demonstrate their responses were not due to chance alone. At the arterial bleed simulation, the T1A for the trained and untrained groups, respectively, were 34.75 seconds and 111 seconds (p-value = .1064), while the TtS were 3 minutes and 33 seconds in the trained group and eight minutes in the untrained groups (physiologic cutoff) (p-value = .0014). At the airway obstruction simulation, the T1A for the trained and untrained groups, respectively, were 20.5 seconds and 43 seconds (p-value = .1064), while the TtS were 32.6 seconds in the trained group and 7 minutes and 3 seconds in the untrained group (p-value = .0087). Simulation values for recently graduated nursing students and a local fire department engine company (emergency medical services [EMS]) were also given for reference. The trained group\u27s results mirrored times of EMS. CONCLUSION: This study demonstrates an effective training model to civilian trauma response, while adhering to established recommendations. We offer our model as a potential solution for accomplishing the Stop The Bleed mission while advancing the potential of public disaster response